Oral Exam Scripts
Professor-style Q&A · Start the timer, speak your answer aloud, then reveal and compare · 25 questions
Oral Escalation Protocol
Apply twice: countdown from 2026-06-04 (Exam 1, 8d) and 2026-06-18 (Exam 2)
What are the differences between acute and chronic inflammation? Include key cell types.
Explain the mechanism of fever from stimulus to hypothalamic set-point elevation.
Describe the adhesion molecule cascade for neutrophil extravasation.
Differentiate exudate from transudate. Give clinical examples.
Compare apoptosis and necrosis. Include morphology, mechanism, and inflammatory response.
Explain the role of p53 in normal cells and in cancer. What is the dominant negative effect?
What is the difference between benign and malignant neoplasia?
Explain the multistep carcinogenesis model. Name two key driver mutations.
Describe the metastatic cascade. Which step is rate-limiting?
What is EMT and which transcription factors orchestrate it?
State Knudson's two-hit hypothesis using retinoblastoma.
How does PTEN loss create immunotherapy resistance?
Compare autosomal dominant and autosomal recessive inheritance with examples.
Explain genomic imprinting using Prader-Willi and Angelman syndromes.
Compare T1DM and T2DM pathophysiology.
Explain the four mechanisms of diabetic microangiopathy.
Classify anemias by MCV. Give one example per category.
Define hypertrophy, hyperplasia, atrophy, and metaplasia with examples.
What is the role of CAFs (cancer-associated fibroblasts)?
Define exosomes and their role in metastasis.
Explain endocrine therapy in ER+ breast cancer.
Describe autophagy and its dual role in cancer.
Differentiate Hodgkin from non-Hodgkin lymphoma.
Compare Graves disease and Hashimoto thyroiditis.
Explain the role of mitochondria in apoptosis.